FAGOAQUA
Characterization of a Lytic Phage from Urban Wastewater against Multidrug Resistant Bacteria
DOI:
https://doi.org/10.56007/arrivet.v1i3.56Keywords:
Bacteriophage, MDR, WWTPAbstract
Antimicrobial resistance is a critical global health threat, directly causing 1.27 million deaths in 2019 (Murray et al., 2022). Wastewater treatment plants (WWTPs) act as significant hotspots where multidrug-resistant (MDR) bacteria persist and spread into the environment (Godinho, Lage, & Quinteira, 2024). At the same time, these systems represent dynamic environments that promote high bacteriophage diversity and host–phage interactions. The FAGOAQUA project aims to isolate and characterize MDR bacterial strains and their associated lytic phages from wastewater. Experimental results confirmed the isolation of several MDR strains, specifically Raoultella ornithinolytica, Citrobacter freundii, and Proteus mirabilis, all of which exhibited different resistance levels to multiple antimicrobial classes. Concurrently, a lytic bacteriophage was isolated and characterized, demonstrating lytic activity against one of these strains. Together, these results highlight the value of wastewater environments as reservoirs for the identification of phages with potential applicability in the targeted control of antibiotic-resistant bacteria.
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